ACE2 protein – Communicable Diseases Research

Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility

Research article

Published on 2022-10-012022-10-05
Journal: Infection, genetics and evolution : journal of mol
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

SARS-CoV-2 spike protein enhances MAP4K3/GLK-induced ACE2 stability in COVID-19

Article

Published on 2022-09-072022-10-06
Journal: EMBO Molecular Medicine
[Category] COVID19(2023년), SARS, 진단,

Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking

Article

Published on 2022-09-022022-11-16
Journal: Human Genomics
[Category] SARS, 변종,

[키워드] ACE2 ACE2 gene ACE2 protein ACE2 receptor ACE2 variant acting acute respiratory syndrome Amino acid Analysis angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approach binding characterization clinical manifestation contribute COVID-19 Critical Deleterious demonstrated domain Effect enzyme explain expression genetic variability Genetic variation Human human cell in silico analysis Infection Missense missense variant plasma membrane polymorphism predicted RAS receptor renin-angiotensin system required S protein SARS-CoV-2 selected sequence severity significant effect subcellular subcellular localization Subcellular trafficking. suggested susceptibility the SARS-CoV-2 the spike protein transmembrane type I variant Variation viral spike viruses
[DOI] 10.1186/s40246-022-00411-1 PMC 바로가기

An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infection

Research article

Published on 2022-08-012022-10-05
Journal: Computers in biology and medicine
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 ACE2 protein acute respiratory syndrome ADAM17 Affect affected Algorithm analyzed ASGR1 Asialoglycoprotein Basigin Bone marrow Brain caused CD147 Cell CLEC4M Cluster Clustering Coronavirus-2 COVID-19 COVID-19 infection cytoplasm Differential evolution algorithm disease disintegrin domain drug effective Effectiveness eliminating entry of SARS-CoV-2 enzyme Evolution population dynamics exploratory expresse expression profile EXT1 EXT2 EXT3 Factor fusing Fuzzy clustering G protein-coupled receptor genetic diversity GLCE Glucuronic acid GPR78 Grey Grey wolf optimizer help Host host cell host cell membrane host receptor humans hybridizing I, II identify identifying IHC immunohistochemistry individual Infection inhibiting Interaction intestine kidney KREMEN1 Kringle liver lung mechanism membrane protein Membrane proteins Mutation NDST2 neuropilin NRP1 operator pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathogenicity protease Protein PVR receptor replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus serine protease Seurat shown Single cell RNA sequencing data single-cell Spike protein spleen Spread therapeutic target TMPRSS2 toolkit transcriptionally transcriptomics transmembrane protein Transmission virus XYLT1 XYLT2
[DOI] 10.1016/j.compbiomed.2022.106050 [Article Type] Research article

Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19

Research article

Published on 2022-08-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar
[Category] 바이오마커, 치료기술,

[키워드] ACE ACE2 ACE2 expression ACE2 protein acute respiratory syndrome Analysis Ang II angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitors blockade cause circulating control group coronavirus COVID-19 COVID-19 group COVID-19 patient COVID-19 patients enzymatic activity etiological agent healthy healthy subjects Hospitalized hypertension hypertensive hypertensive patient investigated medications normotensive not different Patient patients protein level RAS receptor remained renin-angiotensin system reported Result significantly Support treated Treatment were excluded were measured with COVID-19
[DOI] 10.1016/j.biopha.2022.113201 [Article Type] Research article

Engineering defensin α-helix to produce high-affinity SARS-CoV-2 spike protein binding ligands

고친화성 SARS-CoV-2 스파이크 단백질 결합 리간드를 생성하기 위한 디펜신 α-나선 공학

Article

Published on 2022-06-012022-09-11
Journal: Protein Science : A Publication of the Protein Soc
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Amino acid amino acid residue amino acid residues angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacterial binding binding ligand blocked class competitive inhibition coronavirus COVID-19 Critical defensin demonstrated diagnostic diagnostics disrupt Disulfide Engineering exceptional expressed expression high-affinity binding homogeneity host cell host cells initial Interaction kDa Ligand ligands Protein protein-protein interaction purified receptor residue SARS-CoV-2 SARS-CoV-2 diagnostics SARS-CoV-2 neutralizing antibodies SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus soluble ACE2 Spike protein spike-protein spike-protein. the SARS-CoV-2 the spike protein therapy viral infection were used α-helix
[DOI] 10.1002/pro.4355 PMC 바로가기 [Article Type] Article

Human-to-dog transmission of SARS-CoV-2, Colombia

콜롬비아, SARS-CoV-2의 사람에서 개 전염

Article

Published on 2022-05-122022-09-11
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] ACE2 protein acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 causative agent clade close contact Complete conservation contribute coronavirus 2 COVID-19 pandemic docking E484K E484K mutation events Genome help hosts Human Latin America Lineage Localization molecular analysis Mutation non-human primates Phylogenetic prediction Prevent Protein protein structure public health RBD receptor Receptor-binding domain respiratory SARS-CoV-2 sequenced Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein symptomatic the receptor-binding domain the Spike Transmission transmission of SARS-CoV-2 viral infection viral sequence viral sequences virus
[DOI] 10.1038/s41598-022-11847-9 PMC 바로가기 [Article Type] Article

Understanding the Driving Forces That Trigger Mutations in SARS-CoV-2: Mutational Energetics and the Role of Arginine Blockers in COVID-19 Therapy

SARS-CoV-2에서 돌연변이를 유발하는 원동력 이해: 돌연변이 에너지와 COVID-19 치료에서 아르기닌 차단제의 역할

Article

Published on 2022-05-112022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종,

[키워드] 3CLpro accelerated ACE2 ACE2 protein Alpha Amino acid amino acids angiotensin Angiotensin receptor blockers angiotensin type1 receptor Angiotensin-converting enzyme anionic antiviral drug arginine assist association Beta binding biphenyl bisartans blocker blockers candidate drug cleavage site cleavage sites complex complexes Computational approaches conformation conformational contribute COVID-19 COVID-19 therapy Critical Delta delta variant driving drug energetics ENhance equilibrium Evolution of SARS-CoV-2 force furin furin cleavage site Gamma human clinical trials human population hydrolysis hydropathy hydrophilic hydrophobic interaction in silico Infection Interaction interactions interface investigated Lambda molecular Molecular biology molecular dynamic simulations molecular dynamics mutant mutants mutate Mutation omicron Omicron variants pharmacophores polar Protein RBD RBD binding RBD-ACE2 receptor Receptor-binding domain referred to replacement Replication Research residue residues role S-protein salt salt bridges SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 virus Sartans. Spread suggested target targets tetrazole the RBD the receptor-binding domain the SARS-CoV-2 virus Therapies translation Treatment treatment of COVID-19 Trigger understanding variant variants viral infection virus wild-type virus π-π interaction
[DOI] 10.3390/v14051029 PMC 바로가기 [Article Type] Article

Genetic Landscape of the ACE2 Coronavirus Receptor

ACE2 코로나바이러스 수용체의 유전적 지형

Meta-Analysis

Published on 2022-05-032022-09-11
Journal: Circulation
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] ACE2 ACE2 protein Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biological systems blood immune cells cardiometabolic cardiovascular disease cardiovascular diseases cardiovascular diseases. Cell cell type circulating Clinical studies clinical study Combined complex complex disease conducted coronavirus correlated correlation COVID-19 COVID-19 severity cross-sectional Diseases DNA methylation elevated epidemiological epigenomic expressed functional gastrointestinal tracts Genetic genetic architecture Genome genome-wide association Genome-wide association study heart heritability Hospitalization Human human cell human cells immune cells in silico individual Infection landscape likelihood loci mapped medications mendelian randomization Meta-analysis Odds ratio outcome Phenotypes plasma Protein Quantitative randomization receptor Regulatory related diseases resource respiratory SARS-CoV-2 severe COVID-19 soluble ACE2 suggested tissue transcriptomic Treatment variant Vascular vascular disease vascular diseases
[DOI] 10.1161/CIRCULATIONAHA.121.057888 PMC 바로가기 [Article Type] Meta-Analysis

Immunopathological changes, complications, sequelae and immunological memory in COVID-19 patients

Review article

Published on 2022-04-262022-10-05
Journal: Heliyon
[Category] 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 protein ACE2 receptor antibody binding Care cell death changes Complication complications Confirmed COVID-19 COVID-19 patient COVID-19 patients death disease elevated evaluated expressed Health Immunity immunological change Immunological memory immunopathology increased risk Inflammation long-term health problem lung tissue major organs majority management Mild moderate multiple organ multiple organs Organ failure Pathogenesis prevalent problem reached receptor reduced Reinfection risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus sequelae severe complication Survivors susceptibility Symptoms Syncytia vaccination
[DOI] 10.1016/j.heliyon.2022.e09302 [Article Type] Review article